AKT1 and hereditary clear cell renal cell carcinoma: Wei et al. found that nobiletin (a poly-methoxy flavonoid isolated from Citrus depressa and Citrus reticulata) can decrease renal cell carcinoma volume and weight by reducing the levels of phosphorylated Src, phosphorylated AKT, serine/threonine kinase, and phosphorylated STAT3 [74].