As sarcopenia progresses, the expression of MFG-E8 increases, which hinders the process of mitophagy by reducing the levels of important components like Parkin, PTEN-induced kinase 1 (PINK1), and microtubule-associated proteins 1A/1B light chain 3B (LC3B)-II/I ratio. This evidence concerns the gene PINK1 and sarcopenia.