A large retrospective study showed that the cumulative index of the inflammatory response, calculated based on the level of high-sensitivity CRP (hsCRP) and total leukocyte count on days 2–3 of follow-up in patients with MI CS, was inversely correlated with left ventricular ejection fraction and directly correlated with the lactate level and SCAI severity. This evidence concerns the gene CRP and Cowden syndrome 1.