An increased innate immune response at day 1 of CS development, manifested by neutrophilia and an increased production of IL-6, IL-10, and Monocyte Chemoattractant Protein-1 (MCP-1), correlated with the severity of CS and was followed by the development of immune insufficiency in the form of decreased levels of monocytes and lymphocytes at days 3 and 7. Here, IL6 is linked to Cowden syndrome 1.