TLR4 and neoplasm: In this cancer, miR-345-5p functions as a tumor suppressor by targeting C-C motif chemokine ligand 8 (CCL8) [213]; on the other hand, in the same cancer, the induction of NK cells by a D-glucan from Strongylocentrotus nudus eggs [214] can inhibit cancer growth by stimulating the TLR4/MAPKs/NF-κβ signaling pathway [215,216].