In the latter, ncRNAs can modulate drug efflux, cell apoptosis, and autophagy [91]; for example, there are long non-coding RNAs (lncRNAs) that promote tumors, such as LINC01559 and UNC5B-AS1; these are upregulated in pancreatic ductal adenocarcinoma (PDAC) and are regulators of aerobic glycolysis in PDAC [92], as well as modulators of innate and acquired immunity through the tumor necrosis factor alpha (TNF-α) [93]. This evidence concerns the gene TNF and pancreatic ductal adenocarcinoma.