IL18 and adult-onset Still disease: Genetic factors in SJIA include the presence of the human leukocyte antigen (HLA)—Bw35, DR2, DR4, DR5, and Dw7— as well as the presence of macrophage migration inhibitory factors (MIFs), IL6, IL18, TNFα polymorphisms, and, in AOSD, HLA- Bw35, DR2, DR4, DRB1, Dw7, and MIFs, which are IL18 polymorphisms [5].