As for second task, the insufficient level of increase of blood NT-proBNP, within the reference values (68 [35–108] pg/mL, median with interquartile range 25–75%), also demonstrated the “imperfection” of natriuretic peptides, which means the ineffectiveness of its use in the diagnosis of subclinical LVD in T2D [39]. This evidence concerns the gene NPPB and type 2 diabetes mellitus.