P2RY12 and myocardial infarction: The ON-TIME 3 (The Opioids and crushed Ticagrelor In Myocardial infarction Evaluation) trial investigated nonopioid analgesics (intravenous acetaminophen) to increase the bioavailability of oral P2Y12 inhibitors in STEMI patients and to reduce the likelihood that patients will still have high platelet reactivity [63] when undergoing a PPCI.