The results showed that the expression of PINK1, PRKN (same as Parkin), LC3B, and SOD2 were down-regulated in LHON-IFBs after SkQ1 (20 nM) treatment compared with the control group, regardless of H2O2 (200 μM/6 h)-induced or non-induced (Figure 7A–D). The gene discussed is SOD2; the disease is Leber hereditary optic neuropathy.