This study also identified A-Eos and B-Eos in the GI tract of patients with inflammatory bowel disease (IBD) and healthy controls using immunofluorescence assays to MBP and PD-L1 and found that A-Eos (MBP+PD−L1+) were localized closer to the lumen than B-Eos (MBP+PD−L1−) and were substantially increased in patients with IBD compared to healthy controls. Here, CD274 is linked to inflammatory bowel disease.