The authors then compared the transcriptome of eosinophils isolated from the colon of mice undergoing dextran sulfate sodium (DSS)-induced colitis (a model characterized by high exposure to microbes and IFNɣ) and eosinophils isolated from the lungs of mice with experimental asthma (characterized by high exposure to IL-4) to the transcriptomes of type 1- and type 2-stimulated eosinophils from their in vitro experiments. This evidence concerns the gene IFNA1 and asthma.