IKBKB and cancer: For example, increased RNA and protein expression of atrogin-1 together with MuRF-1 were found with myocardial or skeletal muscle wasting in a Lewis lung cancer mouse model and attributable to NF-κB activation due to increased Iκκβ and phospho-p65 expression [17], as NF-κB inhibition via luteolin largely reversed E3 ligases and losses in cardiac and skeletal muscle mass.