PDCD1 and Autoimmunity: Cancer continued to be the most common disease targeted by drugs, followed by autoimmune conditions, and the most common targets included TNF, PD-1, CD3, CD20, HER2, FcRn, IL-23 p19 subunit, and other interleukins, and calcitonin gene-related peptide, plus an exogenous source of enzymes [2,3,6].