Whether IL-6 released by macrophages and monocytes in the inflammatory response can directly stimulate thirst and water intake—as well as increase vasopressin secretion by osmoreceptors in neurons from the supraoptic and paraventricular nuclei in the hypothalamus, consequently leading to SIADH [19]—remains to be elucidated in the COVID-19 setting. Here, IL6 is linked to inappropriate ADH syndrome.