Free thrombin, F1+2, TAT, and APC were significantly increased (p ≤ 0.011) in the plasma of both the COVID-19 and non-COVID sepsis cohorts compared to healthy controls stimulated with rFVIIa, with median thrombin levels of 0.54, 0.48, and < 0.46 pmol/L, F1+2 levels of 846, 360, and 209 pmol/L, TAT levels of 185, 146, and 31 pmol/L, and APC levels of 7.4, 10.5, and 3.1 pmol/L, respectively (Figure 3A–D). Here, APC is linked to COVID-19.