The ratio of APC to thrombin did not differ statistically significantly between the three cohorts (Figure 4A), whereas the medians of APC/F1+2 and APC/TAT were approximately 4-fold and 3-fold lower, respectively, in the COVID-19 cohort than in stimulated healthy controls (p = 0.011 and p = 2 × 10−4, respectively). Here, APC is linked to COVID-19.