IQGAP1 and malignant colon neoplasm: However, Zhang et al. [30] found that DNAJB6 expression was upregulated in colon cancer tissues, and increased DNAJB6 expression was significantly associated with poor prognosis, playing a tumorigenic role in colon cancer by upregulating IQGAP1 and activating the extracellular signal-regulated kinase signaling pathway.