The differences in the fat tissue distribution (highlighted by predominantly subcutaneous fat in the gluteofemoral region in females and visceral fat in males) and activity (highlighted by the release of free fatty acids, inflammatory cytokines, and adipokines predominantly by visceral adipose tissue) are established causes for the differences in adiponectin levels and energy and lipoprotein metabolism, as well as susceptibility for metabolic disorders between females and males [43,44,45,46,47]. This evidence concerns the gene ADIPOQ and metabolic disease.