While CAFs-S1 stimulate cancer cell migration and initiate an EMT through CXCL12 and TGFB pathways, highly contractile CAFs-S4 induce cancer cell invasion in 3 dimensions via NOTCH signaling (NOTCH1, bSE = 3.0; NOTCH2, bSE = 2.6; NOTCH3, bSE = 1.4; NOTCH4, SE = 3.0). Here, NOTCH1 is linked to cancer.