In BC, DKK3 orchestrates a concomitant activation of β-catenin and Yes-associated Protein 1 (YAP)/TAZ, where β-catenin is dispensable for CAFs-mediated ECM remodeling, cancer cell growth, and invasion, but DKK3-driven YAP/TAZ activation is required to induce tumor-promoting phenotypes. Here, DKK3 is linked to breast cancer.