CRELD2 and breast cancer: Among them, SPARC expression was closely (R = 0.6 or beyond) correlated with the following genes according to R-index in BC: BNP3L, followed by ITGAV, NFKB2, AKT3, ADAM10, IGF1R, MAPK14 (p38), MAPK1 (Erk2), AKT1, CRELD2, TGFBR2, and NOTCH2 (Figure 5c).