Semi-CAFGs in CRC were defined as SE ratio = 5 or beyond plus below 10 with R-index with SPARC of 0.9 or beyond (Figure S1a), and such genes have also been reported in BC like TIMP3, RARRES2, TIMP2, NOTCH4, IGFBP6, ST6GALNAC5, and TGFB1. This evidence concerns the gene TIMP3 and breast cancer.