Semi-CAFGs in CRC were defined as SE ratio = 5 or beyond plus below 10 with R-index with SPARC of 0.9 or beyond (Figure S1a), and such genes have also been reported in BC like TIMP3, RARRES2, TIMP2, NOTCH4, IGFBP6, ST6GALNAC5, and TGFB1. The gene discussed is ST6GALNAC5; the disease is breast cancer.