SPARC and breast cancer: Semi-CAFGs in CRC were defined as SE ratio = 5 or beyond plus below 10 with R-index with SPARC of 0.9 or beyond (Figure S1a), and such genes have also been reported in BC like TIMP3, RARRES2, TIMP2, NOTCH4, IGFBP6, ST6GALNAC5, and TGFB1.