In addition and in both in-vitro and in-vivo models of HCC, NPAS2-mediated inhibition of CDK2/4/6 and B-cell lymphoma 2 (BCL-2) phosphorylation by upregulating CDC25A has been reported to promote cell proliferation by inhibit mitochondrial apoptosis [89]. This evidence concerns the gene BCL2 and hepatocellular carcinoma.