In terms of the microvascular complications of diabetes, an increase in PKC activation contributes to increased vascular permeability and neovascularization in the retina, leads to alterations in glomerular filtration and boosts the production of extracellular matrix proteins in the kidney, and affects nerve function directly by altering neuronal signaling and survival, as well as through its impact on blood vessels [27,28]. Here, PRRT2 is linked to diabetes mellitus.