For example, SIRT7 alleviates renal ferritin deposition, lipid peroxidation, and pEMT under hypertensive conditions through the enhancement of the KLF15/ nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway, which ameliorates renal fibrosis, injury, and dysfunction [45]. This evidence concerns the gene NFE2L2 and renal fibrosis.