Type I diabetes mellitus (DM I) is classified by a lack of proper insulin production in the pancreas due to the destruction of insulin-producing pancreatic beta cells and it is normally first presented in adolescence, while type 2 diabetes (DM II) is characterized by decreased insulin secretion from the pancreas or the inability to use the secreted insulin, termed insulin resistance, due to prolonged hyperglycemia. The gene discussed is INS; the disease is type 2 diabetes mellitus.