APOE and Alzheimer disease: Genotype investigation showed a higher frequency of APOE ε3/ε4 genotypes in AD patients (OR 3.43, 95% CI [2.95–3.99], p < 0.0001) and of APOE ε4/ε4 in AD patients compared to controls (OR  =  7.08, 95% CI [4.22–11.86]), p < 0.0001), indicating a strong association with AD patients (Figure 8).