We also found a statistically significant association among APOE ε2, APOE ε3, and AD with a low positive rate ((OR = 0.47; 95% CI [0.29–0.74], p = 0.0013; OR = 0.49; 95% CI [0.37–0.65], p < 0.0001, respectively)) for both alleles, thus underscoring their lower risk of developing AD. Here, APOE is linked to Alzheimer disease.