Genes elevated in the Wnt/β-catenin and TGF-signaling pathways are associated with lower numbers of certain CD8+ TILs [47], while pathways like aPKC-I [137], P-Sp1/Snail [137], and Fas/FasL [138] are involved in immunosuppression and tumor cytotoxicity. This evidence concerns the gene CD8A and neoplasm.