GLP-1 agonists, also referred to as GLP-1 receptor agonists (GLP-1 RAs), incretin mimetics, or GLP-1 analogs, are a class of medications used to manage type 2 diabetes mellitus (T2DM) and, in certain cases, obesity. The gene discussed is GCG; the disease is obesity due to melanocortin 4 receptor deficiency.