SOX2 and posterior cortical atrophy: Accordingly, inhibition of fatty acid intake by using anti-CD36 antibodies resulted in the reduction in Wnt5 and SOX2 expressions by CAFs and PCa cells, respectively, decreased proliferation and elevated apoptosis in mice fed with high-fat diet and treated with enzalutamide, suggesting a role for saturated fatty acid signaling in mediating cancer progression and therapy resistance [172].