Recently, Ippolito et al. identified the axis sirtuin 1 (SIRT1)/peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1α) as a crucial player in the CAF-dependent mitochondrial re-education of PCa cells and a marker of PCa invasiveness [165]. The gene discussed is PPARGC1A; the disease is posterior cortical atrophy.