AR signaling has been recognized as the major molecular driver of PCa progression and many pieces of evidence showed how this hormone-sensitive transcription factor is crucial to rewire PCa metabolism toward OXPHOS and DNL during oncogenic transformation by regulating several downstream effectors, including mitochondrial pyruvate carrier (MPC), estrogen-related receptor ERRγ, μTOR and fatty acid synthase (FASN) [145,146,148,155,156]. This evidence concerns the gene ESRRG and posterior cortical atrophy.