PML and acute promyelocytic leukemia: The hallmark of APL is the balanced reciprocal translocation t (15;17) (q24.1;q21.1), resulting in the fusion of the promyelocytic leukemia (PML) gene on chromosome 15 with the retinoic acid receptor α (RARα) gene on chromosome 17, leading to the PML::RARA fusion gene [2].