MMP2 and familial pancreatic carcinoma: Also, it was proven that resveratrol (12.5 μM, 25 μM, 50 μM) impaired the expression of EMT-related genes, including MMP-2 and MMP-9, in pancreatic cancer; such inhibition via the suppression of the NF-κB, PI3 K/Akt and uPA pathways reduced cell proliferation, invasion, and metastasis in a concentration-dependent manner [123,124].