AKT1 and cancer: In particular, the anti-cancer properties of quercetin result from its ability to promote apoptosis, prevent cell arrest, and suppress metastasis and angiogenesis by modulating various intracellular signaling pathways, such as Wnt/β-catenin, PI3 K/Akt, Janus kinases/signal transducer and activator of transcription proteins (JAK/STAT), MAPK, p53, and NF-κB [81,82].