In CL1-5 cells, another lung cancer cell line characterized by high invasiveness, EGCG treatment inhibited MMP-2 and MMP-9 at the mRNA and protein levels and reduced enzymatic activity; it also suppressed MMP-2 promoter activity in a concentration-dependent manner and reduced the nuclear translocation of NF-κB and cell invasion and migration [60]. The gene discussed is NFKB1; the disease is lung cancer.