In a model of oral cancer, resveratrol suppressed the metastasis and invasion of H-357 cells by inhibiting the activity of MMP-2 and MMP-9 and numerous inflammation mediators, e.g., NF-κB, COX-2, inducible nitric oxide synthase (iNOS), TLR4, TNF-α, interleukin-1 β (IL-1 β), and interleukin-6 (IL-6). Here, MMP2 is linked to lip and oral cavity carcinoma.