In endometrial adenocarcinoma, immunohistochemical analysis of xenograft tumor sections in female six-week-old non-obese diabetic SCID (NOD-SCID) mice previously injected with Ishikawa cells demonstrated that curcumin treatment inhibited the expression of MMP-2 and MMP-9 and limited tumor growth observed after 31 days of treatment, which was not associated with any toxic effects, and the mean body weight of the animals remained stable [32]. This evidence concerns the gene MMP2 and neoplasm.