PKM and cancer: Transcriptomic studies showed that solute carrier family 7 member 11 (SLC7A11), solute carrier family 7 member 5 (SLC7A5), Runt-related transcription factor 1 (RUNX1), laminin subunit alpha 4 (LAMA4), collagen type VI alpha 3 chain (COL6A3), phosphoinositide-dependent kinase-1 (PDK1), cyclin A1 (CCNA1), enolase 1 (ENO1), pyruvate kinase muscle isozyme (PKM), nuclear receptor subfamily 2 group F member 1 (NR2F1), and N-acetylated alpha-linked acidic dipeptidase 2 (NAALAD2) are directly associated with the KEGG signaling pathway, the central carbon metabolism in cancer (hsa05230) [4].