Over the last decade, Diaph1 has gained attention as a significant contributor to the pathogenesis of a few neurodegenerative disorders, such as Alzheimer’s, Parkinson’s, Huntington’s, and Creutzfeldt–Jakob’s disease, and various neurodegenerative conditions, such as diabetic neuropathy, amyotrophic lateral sclerosis, amyloid polyneuropathy, Charcot neuropathy, vasculitis neuropathy, and cancer [8,12,14,67]; however, the detailed mechanisms of the Diaph1 contribution to disorders remain unclear (https://www.proteinatlas.org/ENSG00000131504-DIAPH1/pathology, accessed on 1 August 2024). This evidence concerns the gene DIAPH1 and amyotrophic lateral sclerosis.