KIFC1 and cancer: The most studied microtubule-binding protein, the minus-end directed kinesin-14 motor protein, KIFC1 (also known as Human Spleen, Embryo, and Testes motor protein or HSET), drives centrosome clustering in cancer cells by localizing between spindle microtubules, crosslinking, and sliding antiparallel microtubules and bundling them near the spindle poles to induce centrosome coalescence [28,29].