In endometrial cancer, the overexpression of CDCA8 resulted in decreased levels of p53 and Rb; in contrast, CDCA8 knockdown resulted in an increase in p53 and Rb levels, implying that CDCA8 plays a role in regulating the steady-state levels of these proteins in endometrial cancer and likely regulates the activation of pathways downstream of p53/Rb [94]. The gene discussed is RB1; the disease is endometrial cancer.