CUBN and Miyoshi myopathy: In subjects with normal Ig levels, the mean half-life ranges from 1.3 to 1.9 days, whereas in bone marrow transplant recipients, Igs display an extended half-life (from 3.5 to 12.5 days) that rises to 56.5 days in patients with chronic lymphocytic leukemia or MM [20,21,22,23].