In order to establish whether the 19m28mz-mIL18 CAR T cells had the ability to migrate to the tumor site and elicit their IL18-dependent effects on the endogenous immune system, they were injected into immunocompetent syngeneic mice bearing EL4hCD19+ tumors, and at time points thereafter, tumor tissue was analyzed by imaging mass cytometry (CyTOF). The gene discussed is IL18; the disease is neoplasm.