Immunohistochemical analysis of the tumor section exposed to SIRT2-NBs US (+) revealed a marked increase in cell death confirmed using hematoxylin and eosin (H&E), caspase-3, and terminal deoxynucleotidyl transferase (TdT) dUTP Nick-End Labeling (TUNEL) assay. This evidence concerns the gene SIRT2 and neoplasm.