IHC assessment of apoptosis within the tumor was conducted by evaluating the expression of cleaved caspase 3 in OE19 xenograft tumor tissue microsections and displayed a significant increase in the count of cancer cells with cleaved caspase 3 brown staining out of 100 DAPI-stained total counts of cancer cells (apoptosis index) after in vivo treatment with either BMS-754807 or NPT compared to that of the vehicle (control) group (Figure 6C,D). Here, CASP3 is linked to cancer.