The immunohistochemistry (IHC) analysis of tissue sections from human lung adenocarcinoma primary tumors and matching brain metastases from the cerebral cortex revealed the membrane and cytoplasmic expression of GABRA5 in large pleomorphic tumor cells along the lining of alveolar walls (Figure 1C left panel) and in larger tumor cells in the cerebrum with well-defined borders and surrounding gliotic tissue (Figure 1C right panel). Here, GABRA5 is linked to neoplasm.