Indeed, numerous studies have demonstrated a strong link between liver triacylglycerol accumulation—specifically, when exceeding 55 mg/g liver (5.5%), a threshold indicative of NAFLD—and visceral adipose tissue and insulin resistance, suggesting that liver triacylglycerol plays a crucial role in metabolic dysregulation [50,51,52]. Here, INS is linked to metabolic dysfunction-associated steatotic liver disease.