CEACAM8 and neoplasm: In central tumor samples with a high ratio of M1/M2 macrophages, TANs remained a negative prognostic factor (stromal p < 0.001, intraepithelial p = 0.032) (Figure 4B,C), while in tumors with a low M1/M2 ratio no prognostic relevance of stromal and intraepithelial CD66b+ cell densities was observed (Figure 4D,E).