The only statistically significant difference in average CD8+ TILs/HPF was found between collagen-high and collagen-absent CRC tissues, where collagen-high cancers had a mean of 5.2 CD8+ TILs/HPF versus collagen-absent cancers having a mean of 12.3 CD8+ TILs/HPF (p = 0.004) (Figure 5B). This evidence concerns the gene CD8A and cancer.