Both infiltrating-type primary CRC lesions and rHPG CRCLM were associated with mutations in APC (3⁄5) and TP53 (3⁄5), KRAS, FAT4, DNH5, SMAD, ERBB2, ERBB3, LRP1, and SDK1 (1⁄5). The gene discussed is FAT4; the disease is colorectal carcinoma.