APC and colorectal carcinoma: On the other hand, dHGP was associated with primary CRC tumors with expanding growth patterns and mutations in APC (4⁄5); TP53 (3⁄5); KRAS, PIK3CA, and FAT4 (2⁄5); and BRCA-1, BRCA2, BRAF, and DNAH5 (1⁄5).