Recent studies comparing normal, low-grade intraepithelial neoplasia (LGIN) in early gastric carcinoma using single-cell analysis revealed that the increased expression of DOT1 like H3K79 methyltransferase (DOT1L), a histone methyltransferase, an enzyme, triggers the activation of the Wnt/β-catenin pathway. This evidence concerns the gene DOT1L and intraepithelial neoplasia.