BRAF and skin neoplasm: Hence, taken together, the inhibition of BRAF, more efficiently in combination with UVB light, may constitute a favorable milieu for the persistence and/or reactivation of a latent papillomaviral infection, which allows for skin tumor development similarly to that following chronic immunosuppression in organ transplant patients and as shown previously in cyclosporin A-immunosuppressed MmuPV1-infected mice [28,44].