Therefore, we further investigated how the combination of all three factors—BRAF inhibition, UVB light and papillomaviral infection (in the absence of mutated BRAF and RAS activating mutations)—supports skin carcinogenesis and, more specifically, if the presence of the BRAFi in conjunction with UVB, could have an effect on MmuPV1 infection in inducing skin tumorigenesis. This evidence concerns the gene BRAF and infection.