GPX4 and renal cell carcinoma: Additionally, based on data from The Cancer Genome Atlas (TCGA) and the Genotype-Tissue Expression (GTEx) database, the expression of key ferroptosis regulators such as GPX4, SLC7A11, and FSP1 was found to be significantly upregulated, while ACSL4 expression was notably downregulated in the three major types of RCC [22].