TP53 and thyroid gland carcinoma: In terms of anaplastic thyroid carcinoma, the most aggressive subtype of thyroid cancer, Sandulache et al. reported that the most commonly detected ctDNA mutations in a sample of 23 patients were TP53 and BRAF (65% and 48%, respectively), and treatment-naive patients had higher concordance rates between ctDNA and tDNA [40].