Current approaches for each one of the three different diseases include exeresis of enchondromas for OD, maximal safe tumor resection followed by radio-, with or without chemotherapy according to the WHO tumor grade for IDH mutant gliomas [13], and induction therapy followed by post-remission therapy administration, represented by chemotherapy and/or allogenic stem cell transplantation for AML [10]. This evidence concerns the gene IDH1 and glioma.