Four years ago (2020), when he was thirty-five years old, for the onset of complications associated with cytopenia, such as muco-cutaneous bleeding diathesis, mainly in the oral cavity, with fever and weakness, he was referred to the Emergency Department first and then the Hematology Division, where after performing blood tests (White Cells Count 77.000/mmc, Hb 8.5 g/dL, PLT 10.000/mmc, many blasts) and bone marrow aspiration (80% blasts, NPM1 mutant, FLT3 ITD wt, FLT3 TKD mutant, IDH1 p.Arg132His mutant), the diagnosis of acute myeloid leukemia was made. This evidence concerns the gene NPM1 and acute myeloid leukemia.