Liu et al. [34] found no association of SP-A status with patient’s age, tumour differentiation or disease stage, but positive immunostaining was more frequent among patients with confirmed mutations of the EGFR (HER1) gene (characteristic for some cancers, including pulmonary adenocarcinomas, especially in female non-smoking Eurasian patients), encoding for the epidermal growth factor receptor [34]. This evidence concerns the gene EGFR and neoplasm.