Interestingly, a recombinant fragment of human SP-D (rfhSP-D, a trimer of chains consisting of CRD, neck domain and eight Gly-X-Y triplets) induced apoptosis of cells of both androgen-dependent (LNCaP, p53-wild-type) and -independent (PC3, p53-mutated) lines, explants and primary tumour cells from metastatic patients [57], as well as TRAMP explants [58], suggesting the therapeutic potential of that collectin. This evidence concerns the gene TP53 and neoplasm.