Kaur et al. [60] demonstrated a pro-apoptotic activity of rfhSP-D against pancreatic cancer cells, independently of their p53 status—namely, that product induced cell death via the Fas-mediated pathway in Panc-1, MiaPaCa-2 (both aggressive, p53-mutated) as well as Capan-2 (non-aggressive, p53-wild-type) cells. This evidence concerns the gene TP53 and familial pancreatic carcinoma.