Figure 3B presents the results of the KEGG pathway analysis, revealing 174 pathways associated with common targets. The top 30 pathways were ranked based on significant enrichment and gene count, with the NLRP3 inflammasome signaling pathway, TNF signaling pathway, and pathways in cancer identified as the most prominent. Notably, the NLRP3 inflammasome signaling pathway exhibited lower p-values and higher gene counts compared to other pathways, suggesting its potential as a primary mechanism of action for PHCE in treating NE. Here, TNF is linked to cancer.