USP18 and adenocarcinoma: In addition, the expression of USP18 was significantly different across different histologic types and lymph node metastasis statuses (normal versus interstitial/mucinous adenocarcinoma in COAD patients, p = 0.0001438/0.004078; normal versus adenocarcinoma in READ patients, p = 0.003756) (Figure 2C,G).