In addition, we also found that the expression of immunosuppressive molecules, including PD-L1, PD-1, LAG3, TNFSF13B and IDO1, was enriched and positively correlated with high USP18 expression, which further suggested that USP18 plays an important role in regulating antitumor immunity in CRC. The gene discussed is USP18; the disease is colorectal carcinoma.