As depicted in Figure 1A, USP18 expression was upregulated in invasive breast carcinoma, colon cancer, head and neck squamous cell carcinoma, lung adenocarcinoma, lung squamous cell carcinoma, esophageal cancer, prostate cancer, bladder urothelial carcinoma, gastric carcinoma, and endometrial carcinoma tissues and downregulated in cutaneous melanoma and renal clear cell carcinoma tissues compared with adjacent noncancerous tissues. This evidence concerns the gene USP18 and malignant colon neoplasm.