Omeprazole also has anti-neoplastic activity demonstrated in CRC [44] and breast [45] cancer cells, and we have previously shown that the growth of an aggressive neuroendocrine cell line NCI-H716, originally of colorectal origin, was curtailed significantly by omeprazole, in a milieu of gastrin added to the tissue culture medium [44]. The gene discussed is GAST; the disease is colorectal carcinoma.