IL6 and Barrett esophagus: The second paper by Lagisetty et al. used RNA sequencing analysis, showing that an incremental increase in a subset of cytokines and chemokines, such as IL-6 and CACLB, was characteristic of progression from BE to EAC and implicated M-2 macrophages, pro-B cells, and eosinophils by xCell deconvolution analysis [20].