Enhanced H3K18la binds to the Rela (p65) and NF-κB1 (p50) promoter regions, activating the NF-κB signaling pathway and upregulating senescence-associated secretory phenotype (SASP) components IL-6 and IL-8, suggesting an H3K18la/NF-κB/SASP positive feedback loop exacerbating brain aging and AD pathology [68]. The gene discussed is NFKB1; the disease is Alzheimer disease.