ART4 and COVID-19: Similarly, LAMP3, a lysosomal glycoprotein that is implicated in adaptive immunity [11], and PRSS8, a cleavage protein with a preference for poly-basic substrates [12], have been found to be associated with COVID-19 severity, as LAMP3 is considered a predictor of severe COVID-19 development, whereas PRSS8 was linked being highly expressed in extra-cellular vesicles of severe-COVID-19 patients [7,8].