On the other hand, ANT2 depletion in renal proximal tubule cells of model mice was found to trigger a cascade of metabolic reprogramming (a switch of metabolism from oxidative phosphorylation to glycolysis), which leads to enhanced renal cell survival and ultimately to the preservation of kidney function in obesity-induced chronic kidney disease [23]. This evidence concerns the gene SLC25A5 and obesity due to melanocortin 4 receptor deficiency.