MTOR and cancer: These metabolic pathways mainly included protein digestion and absorption, central carbon metabolism in cancer, biosynthesis of amino acids, Aminoacyl-tRNA biosynthesis, arginine and proline metabolism, phenylalanine metabolism, valine, leucine and isoleucine biosynthesis, tryptophan metabolism, and mTOR signaling pathway, etc. Differential metabolites mainly included DL-Arginine, DL-Glutamine, Polyphenylalanine, DL-Valine, 4-Aminobutanoic acid, Estradiol, alpha-Ketoisocaproic acid, Uracil, Phenylacetylglycine, Glycocyamine and p-Coumaric acid (Supplementary Figure S6A,B).