To evaluate the role of UBE2C in NCL/EBNA1-mediated curcumol inhibition of NPC invasion and migration, first, we established a nude mouse xenograft tumor model and randomly divided the mice into control, curcumol, shNCL, and shEBNA1 groups (referring to our previous study, the dosage of curcumol was 80 mg/kg once a day) [7]. This evidence concerns the gene NPC1 and neoplasm.